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Important issues about patient history for myasthenic patient
 
Clinical manifestation of myasthenia gravis(MG) patients at different ages
 
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Important issues about patient history for myasthenic patient

Queries about the past patient history are helpful for doctors to make accurate diagnosis and take treatment timely. The queries contents about patient history are included in the following.

1.Common queries: patient’s age, symptoms onset, acute or chronic, gradually developing or quickly developing,whether he/she has manifestations of being angry, being anxious, being tired, being infected, overeating, overworking, overdrinking or being hungry , myoasthenia being persistent or intermittent, whether there is fluctuation or not, its relation with activity, etc.

2.Queries about past history:
(1)Whether patient had epidemic diseases and central myelitis, etc.
(2)Whether patient had contiguity or intoxication due to heavy metal, carbon bisulfide, organoflurine, orgnaophosphorus, organochlorine, botulism, hypermagnesemia, curine.
(3)Whether patient had tumor diseases or immune disease.
(4)Whether there is special genetic disease in family history and inbreeding marriage in direct relatives.

The above aspects are just parts of queries about myasthenic patient. Patients are advised to consult doctors so as to discover disease as early as possible and get timely treatment.
 

Clinical manifestation of MG patients at different ages

1、MG in teenagers
About 4% teenagers with MG occur the disease before 10 years old, 24% before 20 years old, and females are found more than males(4:1). Compared with MG occurred in babies, MG in teenagers is relatively not influenced by genetic factors, but by immunologic mechanism. Its course develops slowly and fluctuates remarkably. And thymoma is uncommon to be observed in teenagers with MG.

2、MG in adults
About 75% adults with MG have symptoms of thymic hyperplasia, and most occur in young people; about 10%-15% of them are found thymoma, which is most common in elderly people. Diseases in male patients develop more quickly than females, with low remission rate and high mortality rate. In the clinical course, there is notable aggravating period and relieving period. About 3/4 patients with tiring ocular muscles, and develop into systemic MG, involving with Laryngopharyngeal muscle. What is more severe, it may involve various muscles and present with asymmetric symptoms. However, the survivals mostly have features of low rate of attacks and relieving symptoms.

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